The Technology was invented by two of the founders of Gonex, Dr. Terry Nett and Dr. Michael Glodé. The technology offers a more convenient and animal friendly alternative to surgical procedures used today for spaying and neutering of animals. With a single injection, it may be possible to permanently sterilize the animal. The product will work in both males and females. Because of the unique mechanism of action, our expectations are that health benefits such as decreased risk of breast and prostate cancers enjoyed through early spaying and neutering would also be achieved with the Gonex injection. Similarly, the behavior benefits of neutering such as aggressive behavior and roaming in males are likely to be achieved with the single injection product.

Mechanism of Action
The gonads in both males and females are stimulated by two hormones secreted by the anterior pituitary gland: luteinizing hormone (LH) and follicle-stimulating hormone (FSH), termed gonadotropins. By chemically linking GnRH, a brain peptide that binds to receptors on the gonadotrope cells, to a protein inhibitor, it is possible to deliver the protein inhibitor specifically to gonadotrope cells that synthesize and secrete LH and FSH in the anterior pituitary gland. The gonadotrope cells will internalize the GnRH conjugate as part of normal cell processes. The internalized complex will cause death of the gonadotrope cell. When the number of gonadotrope cells is adequately reduced, there will be inadequate levels of LH or FSH available to stimulate the gonads and the animal will be sterile.

 

 

 

 

 

 

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